Ted chronic liver disease. We excluded gastrointestinal bleeding and these that had not had paracentesis. The individuals have been divided as outlined by the presence or absence of active infection. We recorded demographic,clinical and laboratory information and assessed the effectiveness of SIRS,CRP,leukocyte count and MPV in predicting infection by utilizing places beneath the curve (AUCs). Results: We identified patients using a imply age of years ( male). Alcohol was identified as a causative agent for liver disease in of patients and in there was chronic viral infection. About of individuals have been classified as ChildPugh C and had criteria for SIRS. The variables CRP ( versus mgL; p),MVP versus . fL; p) and leukocyte count versus .xL; p) had been substantially greater inside the group of sufferers with active infection compared to uninfected. In univariate analysis,the presence of SIRS was connected with infection (X: , p OR. Irrespective of the ChildPugh score,when compared,the variables CRP (AUC:),leukocyte count (AUC:),SIRS (AUC:) and MPV (AUC:),CRP presented the highest discriminating energy,and was statistically superior when when compared with other variables (respectively,p , p , p). This superiority is still maintained no matter whether is analyzed only ChildPugh B patients or in ChildPugh C individuals. Conclusion: The set of our benefits,only identified CRP as a superb marker for exclusion of infection in individuals with decompensated chronic liver disease. PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/23737503 SIRS and also the biomarkers MPV and leukocyte count showed an average discriminatory power (AUC). References . Fernandez J,Navasa M,Gomez J,Colmenero J,Vila J,Arroyo V,et al. Bacterial infections in cirrhosis: epidemiological modifications with invasive procedures and norfloxacin prophylaxis. Hepatology ; : . . Fernandez J,Acevedo J,Castro M,Garcia O,de Lope CR,Roca D,et al. Prevalence and risk things of infections by multiresistant bacteria in cirrhosis: a prospective study. Hepatology ; : . Disclosure of Interest: None declaredP Imply PLATELET VOLUME AS A NONINVASIVE MARKER FOR PREDICTION OF INFLAMMATION AND INFECTION OF ASCITIC FLUID IN DECOMPENSATED CHRONIC LIVER Illness A. G. Antunes ,M. Eusebio ,A. Vaz ,P. Queiros ,T. Gago ,P. Caldeira ,B. Peixe,H. Guerreiro Gastroenterology Division,Centro Hospitalar Do Algarve,Faro,Gastroenterology Department,Centro Hospitalar Do Algarve,Portima o,Portugal Contact Email Address: sergiogiaohotmail Introduction: One of essentially the most vital complication of PP58 biological activity cirrhosis is ascitic fluid infection (AFI) and happens in up to of patients. Current literature suggests that ascitic fluid evaluation by paracentesis should be done for all individuals with ascites which might be admitted to the hospital to exclude AFI. Beside membrane inflammation,AFI is also associated with enhanced systemic inflammation. The mean platelet volume (MPV) as an indicator of bigger,active platelets,is getting widely studied as a marker for systemic inflammation in regions like Cardiology and Rheumatology,because of its low expense and availability in routine analysis (platelet count). Aims Approaches: To evaluate the value of MPV as an inflammation marker in decompensated chronic liver disease its ability to exclude AFI. Retrospective evaluation of all individuals admitted to our center together with the diagnosis of decompensated chronic liver disease,amongst the period of and . We excluded admissions for gastrointestinal bleeding and these exactly where paracentesis was not accomplished. At admission,patients had been divided in groups: with active infection,infected devoid of AFI.