Espir Crit Care Med 161: 646664. 2. Bitterman PB, Rennard SI, Keogh BA, Wewers MD, Adelberg S, et al. Familial idiopathic pulmonary fibrosis. Proof of lung inflammation in unaffected members of the family. The New England journal of medicine 314: 1343 1347. 3. Selman M, King TE, Pardo A Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Annals of internal medicine 134: 136151. four. Moore BB, Hogaboam CM Murine models of pulmonary fibrosis. American journal of physiology Lung cellular and molecular physiology 294: L152160. 5. Wynn TA Integrating mechanisms of pulmonary fibrosis. The Journal of experimental medicine 208: 13391350. 6. Jiang D, Liang J, Hodge J, Lu B, Zhu Z, et al. Regulation of pulmonary fibrosis by chemokine receptor CXCR3. The Journal of clinical investigation 114: 291299. 7. Melhem A, Muhanna N, Bishara A, Alvarez CE, Ilan Y, et al. Antifibrotic activity of NK cells in experimental liver injury through killing of activated HSC. Journal of hepatology 45: 6071. eight. Radaeva S, Sun R, Jaruga B, Nguyen VT, Tian Z, et al. Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2Ddependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners. Gastroenterology 130: 435452. 9. Horikawa M, Fujimoto M, Hasegawa M, Matsushita T, Hamaguchi Y, et al. E- and P-selectins synergistically inhibit bleomycin-induced pulmonary fibrosis. The American journal of pathology 169: 740749. 10. Culley FJ Natural killer cells in infection and inflammation on the lung. Immunology 128: 151163. 11. Kataoka S, Konishi Y, Nishio Y, Fujikawa-Adachi K, Tominaga A Antitumor activity of eosinophils activated by IL-5 and eotaxin against hepatocellular carcinoma. DNA and cell biology 23: 549560. 12. Nishikado H, Mukai K, Kawano Y, Minegishi Y, Karasuyama H NK cell-depleting anti-asialo GM1 antibody exhibits a lethal off-target impact on basophils in vivo. Journal of immunology 186: 57665771. 9 Anti-GM1 Antibody in Pulmonary Fibrosis 13. Slifka MK, Pagarigan RR, Whitton JL NK markers are expressed on a higher percentage of virus-specific CD8+ and CD4+ T cells. Journal of immunology 164: 20092015. 14. Trambley J, Bingaman AW, Lin A, Elwood ET, Waitze SY, et 23148522 al. Asialo GM1 CD8 T cells play a crucial part in costimulation blockade-resistant allograft rejection. The Journal of clinical investigation 104: 17151722. 15. Wiltrout RH, Santoni A, Peterson ES, Knott DC, Overton WR, et al. Reactivity of anti-asialo GM1 serum with tumoricidal and non-tumoricidal mouse macrophages. Journal of leukocyte biology 37: 597614. 16. Kasai M, Iwamori M, Nagai Y, Okumura K, Tada T A glycolipid around the surface of mouse all-natural killer cells. European journal of immunology ten: 175 180. 17. Zaldivar MM, Berres ML, Sahin H, Nellen A, Heinrichs D, et al. The chemokine receptor CXCR3 limits injury after acute toxic liver damage. Laboratory investigation; a journal of technical solutions and pathology 92: 724 734. 18. Eckelhart E, Warsch W, Zebedin E, Simma O, Stoiber D, et al. A novel Ncr1-Cre mouse reveals the vital part of STAT5 for NK-cell survival and development. Blood 117: 15651573. 19. Jessen B, Maul-Pavicic A, Ufheil H, Vraetz T, Enders A, et al. Subtle differences in CTL cytotoxicity ascertain susceptibility to hemophagocytic lymphohistiocytosis in mice and humans with Chediak-Higashi syndrome. Blood 118: 46204629. 20. Kim JH, Kim HY, Kim S, Chung JH, Park WS, et.Espir Crit Care Med 161: 646664. two. Bitterman PB, Rennard SI, Keogh BA, Wewers MD, Adelberg S, et al. Familial idiopathic pulmonary fibrosis. Evidence of lung inflammation in unaffected family members. The New England journal of medicine 314: 1343 1347. three. Selman M, King TE, Pardo A Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Annals of internal medicine 134: 136151. four. Moore BB, Hogaboam CM Murine models of pulmonary fibrosis. American journal of physiology Lung cellular and molecular physiology 294: L152160. five. Wynn TA Integrating mechanisms of pulmonary fibrosis. The Journal of experimental medicine 208: 13391350. 6. Jiang D, Liang J, Hodge J, Lu B, Zhu Z, et al. Regulation of pulmonary fibrosis by chemokine receptor CXCR3. The Journal of clinical investigation 114: 291299. 7. Melhem A, Muhanna N, Bishara A, Alvarez CE, Ilan Y, et al. Antifibrotic activity of NK cells in experimental liver injury by way of killing of activated HSC. Journal of hepatology 45: 6071. 8. Radaeva S, Sun R, Jaruga B, Nguyen VT, Tian Z, et al. Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2Ddependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners. Gastroenterology 130: 435452. 9. Horikawa M, Fujimoto M, Hasegawa M, Matsushita T, Hamaguchi Y, et al. E- and P-selectins synergistically inhibit bleomycin-induced pulmonary fibrosis. The American journal of pathology 169: 740749. ten. Culley FJ All-natural killer cells in infection and inflammation on the lung. Immunology 128: 151163. 11. Kataoka S, Konishi Y, Nishio Y, Fujikawa-Adachi K, Tominaga A Antitumor activity of eosinophils activated by IL-5 and eotaxin against hepatocellular carcinoma. DNA and cell biology 23: 549560. 12. Nishikado H, Mukai K, Kawano Y, Minegishi Y, Karasuyama H NK cell-depleting anti-asialo GM1 antibody exhibits a lethal off-target impact on basophils in vivo. Journal of immunology 186: 57665771. 9 Anti-GM1 Antibody in Pulmonary Fibrosis 13. Slifka MK, Pagarigan RR, Whitton JL NK markers are expressed on a high percentage of virus-specific CD8+ and CD4+ T cells. Journal of immunology 164: 20092015. 14. Trambley J, Bingaman AW, Lin A, Elwood ET, Waitze SY, et 23148522 al. Asialo GM1 CD8 T cells play a vital part in costimulation blockade-resistant allograft rejection. The Journal of clinical investigation 104: 17151722. 15. Wiltrout RH, Santoni A, Peterson ES, Knott DC, Overton WR, et al. Reactivity of anti-asialo GM1 serum with tumoricidal and non-tumoricidal mouse macrophages. Journal of leukocyte biology 37: 597614. 16. Kasai M, Iwamori M, Nagai Y, Okumura K, Tada T A glycolipid around the surface of mouse all-natural killer cells. European journal of immunology ten: 175 180. 17. Zaldivar MM, Berres ML, Sahin H, Nellen A, Heinrichs D, et al. The chemokine receptor CXCR3 limits injury following acute toxic liver damage. Laboratory investigation; a journal of technical procedures and pathology 92: 724 734. 18. Eckelhart E, Warsch W, Zebedin E, Simma O, Stoiber D, et al. A novel Ncr1-Cre mouse reveals the critical role of STAT5 for NK-cell survival and improvement. Blood 117: 15651573. 19. Jessen B, Maul-Pavicic A, Ufheil H, Vraetz T, Enders A, et al. Subtle differences in CTL cytotoxicity establish susceptibility to hemophagocytic lymphohistiocytosis in mice and humans with Chediak-Higashi syndrome. Blood 118: 46204629. 20. Kim JH, Kim HY, Kim S, Chung JH, Park WS, et.