Product Name :
MF498
Description:
MF498 is a novel and selective E prostanoid receptor 4 (EP4 receptor) antagonist, displayed strong binding affinity for the EP4 receptor with Ki of 0.7 nM.Ki value: 0.7 nMTarget: EP4 receptorin vitro: MF498 also displays a relatively good selectivity over other prostanoid receptors, does not compromise the mucosal integrity in the gastrointestinal tract.MF498 inhibits PGE2-stimulated cAMP accumulation in a dose-dependent manner with IC50 values of 1.7 and 17 nM in the absence and presence of 10% serum, respectively. in vivo: MF498 relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis. MF498 on inflammation in adjuvant-induced arthritis (AIA), a rat model for rheumatoid arthritis (RA), and joint pain in a guinea pig model of iodoacetate-induced osteoarthritis (OA).
CAS:
915191-42-3
Molecular Weight:
603.69
Formula:
C32H33N3O7S
Chemical Name:
N-[(4-5,9-diethoxy-6-oxo-6H,7H,8H-pyrrolo[3,4-g]quinolin-7-yl-3-methylphenyl)methanesulfonyl]-2-(2-methoxyphenyl)acetamide
Smiles :
CC1C=C(CS(=O)(=O)NC(=O)CC2=CC=CC=C2OC)C=CC=1N1CC2C(=C(OCC)C3C=CC=NC=3C=2OCC)C1=O
InChiKey:
WVLIUERFVJYBNY-UHFFFAOYSA-N
InChi :
InChI=1S/C32H33N3O7S/c1-5-41-30-23-11-9-15-33-29(23)31(42-6-2)24-18-35(32(37)28(24)30)25-14-13-21(16-20(25)3)19-43(38,39)34-27(36)17-22-10-7-8-12-26(22)40-4/h7-16H,5-6,17-19H2,1-4H3,(H,34,36)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Secnidazole site
Shelf Life:
≥12 months if stored properly.Clotrimazole supplier
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32541217
Additional information:
MF498 is a novel and selective E prostanoid receptor 4 (EP4 receptor) antagonist, displayed strong binding affinity for the EP4 receptor with Ki of 0.7 nM.Ki value: 0.7 nMTarget: EP4 receptorin vitro: MF498 also displays a relatively good selectivity over other prostanoid receptors, does not compromise the mucosal integrity in the gastrointestinal tract.MF498 inhibits PGE2-stimulated cAMP accumulation in a dose-dependent manner with IC50 values of 1.7 and 17 nM in the absence and presence of 10% serum, respectively. in vivo: MF498 relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis. MF498 on inflammation in adjuvant-induced arthritis (AIA), a rat model for rheumatoid arthritis (RA), and joint pain in a guinea pig model of iodoacetate-induced osteoarthritis (OA).|Product information|CAS Number: 915191-42-3|Molecular Weight: 603.69|Formula: C32H33N3O7S|Chemical Name: N-[(4-5,9-diethoxy-6-oxo-6H,7H,8H-pyrrolo[3,4-g]quinolin-7-yl-3-methylphenyl)methanesulfonyl]-2-(2-methoxyphenyl)acetamide|Smiles: CC1C=C(CS(=O)(=O)NC(=O)CC2=CC=CC=C2OC)C=CC=1N1CC2C(=C(OCC)C3C=CC=NC=3C=2OCC)C1=O|InChiKey: WVLIUERFVJYBNY-UHFFFAOYSA-N|InChi: InChI=1S/C32H33N3O7S/c1-5-41-30-23-11-9-15-33-29(23)31(42-6-2)24-18-35(32(37)28(24)30)25-14-13-21(16-20(25)3)19-43(38,39)34-27(36)17-22-10-7-8-12-26(22)40-4/h7-16H,5-6,17-19H2,1-4H3,(H,34,36)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 31 mg/mL (51.35 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|