rmance. Furthermore, certain vitamins and minerals have crucial roles in testosterone synthesis. The importance of supplementing these vitamins and minerals appears to grow to be efficacious when the physique becomes deficient in these certain micronutrients. However, proof supporting any added benefits of supplementing with these micronutrients to augment testosterone concentrations is lacking.Author Contributions: A.Z., T.B.-Z. and J.R.H. all contributed for the writing, editing and the overview of this Nav1.5 Species manuscript. All authors have study and agreed for the published version in the manuscript. Funding: This investigation received no external funding. Conflicts of Interest: The authors declare no conflict of interest.
Assessment published: 25 August 2021 doi: ten.3389/fphar.2021.Applying Next-Generation Sequencing Platforms for Pharmacogenomic Testing in α9β1 manufacturer clinical PracticeAlireza Tafazoli 1,two, Henk-Jan Guchelaar 3,four, Wojciech Miltyk 1, Adam J. Kretowski 2,five and Jesse J. Swen 3,41 Department of Analysis and Bioanalysis of Medicines, Faculty of Pharmacy together with the Division of Laboratory Medicine, Medical University of Bialystok, Bialystok, Poland, 2Clinical Research Centre, Health-related University of Bialystok, Bialystok, Poland, 3 Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, Netherlands, 4Leiden Network of Personalized Therapeutics, Leiden, Netherlands, 5Department of Endocrinology, Diabetology and Internal Medicine, Health-related University of Bialystok, Bialystok, PolandEdited by: Martin A. Kennedy, University of Otago, New Zealand Reviewed by: Eng Wee Chua, Universiti Kebangsaan, Malaysia Chiara Fabbri, King’s College London, Uk Correspondence: Jesse J. Swen [email protected] Specialty section: This article was submitted to Pharmacogenetics and Pharmacogenomics, a section in the journal Frontiers in Pharmacology Received: 11 April 2021 Accepted: 26 July 2021 Published: 25 August 2021 Citation: Tafazoli A, Guchelaar H-J, Miltyk W, Kretowski AJ and Swen JJ (2021) Applying Next-Generation Sequencing Platforms for Pharmacogenomic Testing in Clinical Practice. Front. Pharmacol. 12:693453. doi: ten.3389/fphar.2021.Pharmacogenomics (PGx) research the usage of genetic information to optimize drug therapy. A lot of clinical centers have commenced implementing pharmacogenetic tests in clinical routines. Next-generation sequencing (NGS) technologies are emerging as a additional comprehensive and time- and cost-effective approach in PGx. This review presents the principle considerations for applying NGS in guiding drug treatment in clinical practice. It discusses both the benefits and the challenges of implementing NGSbased tests in PGx. In addition, the limitations of each and every NGS platform are revealed, as well as the options for establishing and management of these technologies in clinical practice are addressed.Keywords and phrases: pharmacogenomics, clinical implementation, subsequent generation sequencing, clinical practice, PGx testingINTRODUCTION The Value of Pharmacogenomics in Modern day MedicinePharmacogenomics (PGx) utilizes individuals’ genomic profiles to recognize those that are at higher risk for adverse drug reactions or ineffectiveness. Several research clearly indicate that drug-related genes, also known as “pharmacogenes,” within the human genome contain in depth functional genetic variations (FGVs) and that various alleles are related with diverse outcomes of drug remedies (Madian et al., 2012; Guchelaar, 2018; Suarez-Kurtz and Parra, 2018). Around 978