Product Name :
SIRT-IN-1
Description:
SIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC50s of 15, 10, 33 μM, respectively.
CAS:
1431411-60-7
Molecular Weight:
389.51
Formula:
C19H27N5O2S
Chemical Name:
4-4-[2-(2,2-dimethylpropanamido)ethyl]piperidin-1-ylthieno[3,2-d]pyrimidine-6-carboxamide
Smiles :
CC(C)(C)C(=O)NCCC1CCN(CC1)C1N=CN=C2C=C(SC2=1)C(N)=O
InChiKey:
NSPKBHVNVJWICU-UHFFFAOYSA-N
InChi :
InChI=1S/C19H27N5O2S/c1-19(2,3)18(26)21-7-4-12-5-8-24(9-6-12)17-15-13(22-11-23-17)10-14(27-15)16(20)25/h10-12H,4-9H2,1-3H3,(H2,20,25)(H,21,26)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Betamethasone dipropionate Autophagy
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
SIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC50s of 15, 10, 33 μM, respectively.|Product information|CAS Number: 1431411-60-7|Molecular Weight: 389.51|Formula: C19H27N5O2S|Chemical Name: 4-4-[2-(2,2-dimethylpropanamido)ethyl]piperidin-1-ylthieno[3,2-d]pyrimidine-6-carboxamide|Smiles: CC(C)(C)C(=O)NCCC1CCN(CC1)C1N=CN=C2C=C(SC2=1)C(N)=O|InChiKey: NSPKBHVNVJWICU-UHFFFAOYSA-N|InChi: InChI=1S/C19H27N5O2S/c1-19(2,3)18(26)21-7-4-12-5-8-24(9-6-12)17-15-13(22-11-23-17)10-14(27-15)16(20)25/h10-12H,4-9H2,1-3H3,(H2,20,25)(H,21,26)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Trospium Data Sheet |Shelf Life: ≥12 months if stored properly.PMID:33200673 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|SIRT-IN-1 (compound 28) is one of the most potent truncated pan SIRT1/ 2/3 inhibitor, the IC50 values are 0.015, 0.010, 0.033 μM, respectively. SIRT-IN-1 (SIRT1/2/3 pan inhibitor) binds identically in the catalytic active site (RMS=0.29 Å), occupying the nicotinamide C-pocket and acetyl lysine substrate channel.|Products are for research use only. Not for human use.|