Product Name :
PS372424
Description:
PS372424, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 prevents human T-cell migration in a humanized model of arthritic inflammation.
CAS:
914291-61-5
Molecular Weight:
588.74
Formula:
C33H44N6O4
Chemical Name:
(2S)-5-carbamimidamido-N-(cyclohexylmethyl)-2-[(3S)-2-(4-oxo-4-phenylbutanoyl)-1,2,3,4-tetrahydroisoquinolin-3-yl]formamidopentanamide
Smiles :
NC(=N)NCCC[C@H](NC(=O)[C@@H]1CC2C=CC=CC=2CN1C(=O)CCC(=O)C1C=CC=CC=1)C(=O)NCC1CCCCC1
InChiKey:
KEDBAZLDJVHMAV-NSOVKSMOSA-N
InChi :
InChI=1S/C33H44N6O4/c34-33(35)36-19-9-16-27(31(42)37-21-23-10-3-1-4-11-23)38-32(43)28-20-25-14-7-8-15-26(25)22-39(28)30(41)18-17-29(40)24-12-5-2-6-13-24/h2,5-8,12-15,23,27-28H,1,3-4,9-11,16-22H2,(H,37,42)(H,38,43)(H4,34,35,36)/t27-,28-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Tiamulin Description
Shelf Life:
≥12 months if stored properly.Daprodustat Biological Activity
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33021854
Additional information:
PS372424, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 prevents human T-cell migration in a humanized model of arthritic inflammation.|Product information|CAS Number: 914291-61-5|Molecular Weight: 588.74|Formula: C33H44N6O4|Chemical Name: (2S)-5-carbamimidamido-N-(cyclohexylmethyl)-2-[(3S)-2-(4-oxo-4-phenylbutanoyl)-1,2,3,4-tetrahydroisoquinolin-3-yl]formamidopentanamide|Smiles: NC(=N)NCCC[C@H](NC(=O)[C@@H]1CC2C=CC=CC=2CN1C(=O)CCC(=O)C1C=CC=CC=1)C(=O)NCC1CCCCC1|InChiKey: KEDBAZLDJVHMAV-NSOVKSMOSA-N|InChi: InChI=1S/C33H44N6O4/c34-33(35)36-19-9-16-27(31(42)37-21-23-10-3-1-4-11-23)38-32(43)28-20-25-14-7-8-15-26(25)22-39(28)30(41)18-17-29(40)24-12-5-2-6-13-24/h2,5-8,12-15,23,27-28H,1,3-4,9-11,16-22H2,(H,37,42)(H,38,43)(H4,34,35,36)/t27-,28-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PS372424 (100 ng/mL) increases p-Erk1 and p-Erk2 in U87-CXCR3-A cells after 5 min of stimulation. PS372424 (10-200 nM; 30 min) causes a concentration-dependent phosphorylation of CCR5 on CXCR3+ T cells not in CXCR3- T cells. PS372424 competes for binding of radiolabeled CXCL10 to membranes prepared from HEK293/CXCR3 Gqi5 cells with an IC50 of 42±21 nM.|Products are for research use only. Not for human use.|