Product Name :
Diatrizoic acid
Description:
Diatrizoic acid (Diatrizoate) is an iodinated radiocontrast agent and has the potential for radiographic imaging of the airways. Diatrizoic acid induces mitochondrial turnover and oxidative stress, and activating apoptosis by dysregulating calcium.
CAS:
117-96-4
Molecular Weight:
613.91
Formula:
C11H9I3N2O4
Chemical Name:
3, 5-diacetamido-2, 4, 6-triiodobenzoic acid
Smiles :
CC(=O)NC1=C(I)C(C(O)=O)=C(I)C(NC(C)=O)=C1I
InChiKey:
YVPYQUNUQOZFHG-UHFFFAOYSA-N
InChi :
InChI=1S/C11H9I3N2O4/c1-3(17)15-9-6(12)5(11(19)20)7(13)10(8(9)14)16-4(2)18/h1-2H3,(H,15,17)(H,16,18)(H,19,20)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Diatrizoic acid (Diatrizoate) is an iodinated radiocontrast agent and has the potential for radiographic imaging of the airways. Diatrizoic acid induces mitochondrial turnover and oxidative stress, and activating apoptosis by dysregulating calcium.|Product information|CAS Number: 117-96-4|Molecular Weight: 613.91|Formula: C11H9I3N2O4|Synonym:|Diatrizoate|Amidotrizoic acid|Chemical Name: 3, 5-diacetamido-2, 4, 6-triiodobenzoic acid|Smiles: CC(=O)NC1=C(I)C(C(O)=O)=C(I)C(NC(C)=O)=C1I|InChiKey: YVPYQUNUQOZFHG-UHFFFAOYSA-N|InChi: InChI=1S/C11H9I3N2O4/c1-3(17)15-9-6(12)5(11(19)20)7(13)10(8(9)14)16-4(2)18/h1-2H3,(H,15,17)(H,16,18)(H,19,20)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (162.89 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.ATPA In Vivo |Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|HK-2 cells are exposed to 0-30 mg I/mL Diatrizoic acid (Diatrizoate) or vehicle for 2-24 h.Rozanolixizumab Autophagy MTT and trypan blue exclusion indicate a decrease in mitochondrial and cell viability within 2 and 24 h, respectively.PMID:31644130 |In Vivo:|Diatrizoic acid is an iodinated radiocontrast agent. Histological examination of rat lung tissue shows no acute toxicity or inflammation after insufflation of Diatrizoic acid nanoparticle agglomerates. Diatrizoic acid nanoparticle agglomerates offers a promising radiocontrast agent for safe and effective lung visualization.|References:|El-Gendy N, et al. Dry powdered aerosols of diatrizoic acid nanoparticle agglomerates as a lung contrast agent. Int J Pharm. 2010 May 31;391(1-2):305-12.Dakota B Ward, et al. Radiocontrast Agent Diatrizoic Acid Induces Mitophagy and Oxidative Stress via Calcium Dysregulation. Int J Mol Sci. 2019 Aug 21;20(17):4074.Products are for research use only. Not for human use.|