E) Vascular pathology score, mean (variety) WML score, mean (range) White matter/Vascular lesions, moderate – serious ( ) Lewy body pathology, number (limbic/neocortical) Neuronal loss in substantia nigra, number (none/mild/moderate/severe) Young Ageing PSND Controls Controls 9 16 18 84.7 (791) 9/9 88.0 (833)* 21.4 1.4* 16.6 1.2* 27.3 (260)* two.6 (1) 1.7 (1) 13.five (134)two.5 (2) one hundred 0/0 AD 18 87.8 (766) 9/9 44.0 (203) 10.0 0.9 12.3 0.six 8.5 (06) 5.6 (five)** two.9 (two)** ten.eight (36) 1.7 (0) 72 0/1 DLB 16 79.6 (696) 7/9 53.eight (240) 14.9 1.1 12.1 1.5 13.eight (60) 2.3 (0) 1.3 (0) 9.6 (73) 1.7 (1) 75 3 / 11 PDD 13 72.eight (641) 5/8 61.1 (394) 16.two 1.1 9.six 0.9 14.two (30) two.1 (0) 0.3 (0) 9.8 (74) 1.8 (1) 92 3/7 Mixed 1 17 83.0 (723) 13 / four 51.0 (238) 13.five 1.six 11.2 0.8 11.9 (29) four.9 (two)** two.7 (0)** ten.6 (33) 1.6 (0) 88 3/5 Mixed 2 14 84.7 (724) 8/6 50.five (411) N/A N/A 14.0 (126) five.two (five)** two.9 (2)** 11.0 (64) 2.8 (two) 95 0/0 VaD 13 88.1 (758) 6/7 62.0 (250) 14.4 1.4 10.eight 1.two 17.3 (84)two.0 (0) 1.0 (0) 13.2 (106)2.9 (two) one hundred 4/0 PSD 19 87.5 (808) 13 / six 61.five (240) 15.0 2.two 11.1 1.9 16.five (120) two.six (1) 1.3 (1) 13.3 (97)two.4 (2) one hundred 0/61.1 86.9 (558)* (729) 5/4 N/A N/A N/A N/A 0.25 (0) 0.0 (0) N/A N/A N/A 0/0 N/A 12 / 4 N/A N/A N/A N/A 1.9 (0) 0.five (0) 6.7 (00) 0.5 (0)17.6** 0/0 N/A18 / 0 / 0 / 0 7 / eight / two / 0 0 / three / 6 / six 0 / 1 / two / 9 3 / four / 7 / 2 14 / 0 / 0 / 0 7 / 4 / 2 / 0 19 / 0 / 0 /Mixed dementia 1: 7 = ADDLB, 6 = ADVaD, 3 = ADDLB VaD and 1 = PDD DLB VaD; Mixed dementia two: all with AD and VaD pathology Age, *P 0.01 vs Ageing Controls and all dementia groups; Total CAMCOG score, CAMCOG executive and memory sub-score and MMSE score, *P 0.01 vs all dementia groups; Braak Stage, **P 0.01 vs Young Controls, Ageing Controls, DLB, PDD and VaD; **P 0.05 vs PSD and PSND; CERAD, **P 0.01 vs Young Controls. Ageing Controls, DLB, PDD, VaD, PSD and PSND Vascular Pathology Score [10], P 0.01 vs all dementia groups; 0.01 vs DLB and PDD; 0.05 vs Mixed 1; WML score, �P 0.01 vs all dementia groups; P 0.01 vs AD, DLB, PDD and Mixed 1; White matter/Vascular lesions, moderate-severe ( ) **P 0.01 vs all dementia groups; Lewy body pathology, only the number of limbic/ neocortical instances are shown. Fourteen Ageing Controls, 15 AD, 6 Mixed 1, all Mixed 2, 9 VaD, all PSD and PSND situations had no Lewy body pathology. Two Ageing Controls, 1 AD, 1 DLB and two Mixed 1 showed Lewy body pathology in brain stem. Data were not available for 1 case in DLB and PDD groups resulting from restricted autopsy; Neuronal loss inside the substantia nigra, information was not out there for 1 case in each and every group apart from VaD, PSD and PSND on account of limited autopsy Abbreviations: AD Alzheimer’s disease, CAMCOG Cambridge Recombinant?Proteins MOB1A Protein Cognition Examination, CERAD Consortium to Establish a Registry for Alzheimer’s Disease, DLB Dementia with Lewy Bodies, F female, M male, Mixed 1, Mixed dementia 1 with AD, DLB, PDD and VaD; Mixed two, Mixed dementia two with AD and VaD, MMSE Mini Mental State Examination, PDD Parkinson’s illness with dementia, PSD post-stroke dementia, PSND post-stroke no dementia, VaD Vascular dementia, WML white matter lesionVascular pathology scores have been derived from the presence of vascular lesions/pathologies in four brain locations, including the frontal lobe in the amount of the olfactory bulbs, temporal lobe at level of the anterior hippocampus, basal ganglia at amount of mammillary physique and middle segment of the hippocampus [10]. Lesions including arteriolosclerosis, cerebral amyloid angiopathy, perivascular haemosiderin leakag.