Composition are strictly linked with nutritional status in cirrhotic sufferers. Metabolomic analyses ought to be performed to reveal the significance of these alterations and to evaluate possible therapeutic approaches. Disclosure of Interest: None declaredP PATHOGENETIC Role OF Smaller INTESTINAL BACTERIAL OVERGROWTH IN NONALCOHOLIC STEATOHEPATITISS. Tkach,T. Cheverda Internal Medicine #,National Medical University,Kyiv,UkraineContact E mail Address: tkachsergioyahoo Introduction: Amongst the numerous potential contributions on the trans-ACPD site microbiota to liver disease,little intestinal bacterial overgrowth (SIBO) has historically been shown to become prevalent in chronic liver disease,to correlate with its severity,to be linked to minimal and overt encephalopathy and increased threat of spontaneous bacterial peritonitis. Most lately,extra credence has been provided to a suggestion that the gut microbiota may well play a role within the pathogenesis or progression of certain liver diseases,which includes alcoholic liver disease,nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) via the direct effects of bacteria or their merchandise,through nflammatory mediators such as tumor necrosis aspect. Aims Solutions: Our aim was to evaluate the frequency of SIBO in sufferers with NAFLDNASH along with the influence of eradication of SIBO on clinical course of NASH. We investigated obese sufferers ( male,mean age years,imply BMI . ,) who have been categorized into two groups: sufferers with liver steatosis and sufferers with NASH. Diagnosis of NALFD was confirm by use of ultrasonography orand computed tomography. Diagnosis of NASH was according to increasing amount of ALT . mmoll) andor constructive outcomes of NASHTest (Poynard et al. In sufferers with NASH the evaluation of liver function with Cmethacetine breath test (CMBT) also was performed (IRIS by WAGNER,Germany). The presence of SIBO was diagnosed by utilizing a hydrogen glucose breath test (ECA Gastrolyzer ,Bedfont Scientific Ltd,Rochester,UK). All patients with constructive final results of hydrogen glucose breath test (HGBT) have been treated with rifaximine ( mgday for the duration of days). The efficacy of therapy was controlled with repeated biochemistry,HGBT and CMBT (immediately after month). Results: Overall,good results of HGBT and presence of SIBO were discovered in pts with liver steatosis and ( with NASH (P). Abnormal final results of CMBT have been occurred in pts with liver PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28550243 steatosis and SIBO versus pts with NASH and SIBO ,P). Eradication of SIBO was accomplished in of pts ( soon after use of rifaximine ( mgday during days). Apparent improvement from the amount of ALTP) and liver function with repeated biochemistry and CMBT (soon after month) was occurred in pts and pts (accordingly. Conclusion: We concluded that the adjustments of intestinal microbiota,like SIBO,plays a crucial pathogenetic function in initiation and progression of NASH. The modulation of intestinal microbiota and eradication of SIBO with antibiotics (rifaximine) decreased the amount of liver inflammation,enhanced biochemical and liver functional indicators and can be viewed as as an effective and prospective system of remedy of NASH. Disclosure of Interest: None declaredUnited European Gastroenterology Journal (S) P Role OF HUMAN UMBILICAL CORDDERIVED MESENCHYMAL STEM CELLS IN MANAGEMENT OF CARBON TETRACHLORIDEINDUCED HEPATIC FIBROSIS IN SPRAGUE DAWELY RATS D. Bakr,M. Maher,A. Lotfy,on behalf of health-related experimental research center,S. El Desouky,on behalf of health-related experimental research center,F. El Huss.