Artile were significantly older than those in the lowest quartile, and the proportion of patients with a previous stroke was significantly higher in the highest quartile. Otherwise, there wereDiscussionThe main finding of our study is that in this sample of older people with mild dementia, WMH were 1326631 not 1948-33-0 associated with OH or low standing systolic BP. Only APOEe4 status (volumetry) and age (volumetry and semi-quantitative analysis) were independently associated with WMH volumes. Thus, our hypothesis that WMH in mild dementia are associated with OH was not supported. This finding is in contrast to some previous studies. However, some of these studies were performed in older people with major depression [16,18,19],OH and WMH in Mild DementiaTable 1. Demographic and clinical characteristics.Total sample Volumetry group (n = 82), vs. rest Semi-quantitative group (n = 139), vs. n = 246 of sample rest of sample Age, median (IQR) Women, n ( ) MMSE, median (IQR) Coronary heart disease, n ( ) Hypertension (history of), n ( ) Diabetes mellitus, n ( ) APOEe4 1 allele, fractions ( ) Previous stroke, n ( ) Smoker (former/pres.), n ( ) Heart failure, n ( ) Orthostatic hypotension (present), n ( ) CIRS score, median (IQR) No. of drugs, median (IQR) 76.9 (71?1) 139 (57) 24 (22?6) 49 (21) 109 (46) 21 (9) 93/153 (61) 33 (14) 111 (48) 12 (5) 90 (46) 6 (4?) 4 (2?) 76.1 (70?1), p = 0.502 51 (62), p = 0.256 24 (22.5?6), p = 0.217 15 (19), p = 0.704 30 (38), p = 0.115 9 (11), p = 0.495 31/53 (59), p = 0.803 8 (10), p = 0.302 37 (47), p = 0.862 2 (3), p = 0.227 35 (47), p = 0.945 6 (4?), p = 0.402 4 (2?), p = 0.159 41 (53), p = 0.167 p = 0.000 138 (56) 89 (36) 11 (4) 8 (3) 60 (73) 16 (20) 2 (2) 4 (5) 76.5 (71?1), p = 0.562 84 (60), p = 0.198 23.3 (22?5), p = 0.377 27 (21), p = 0.949 63 (47), p = 0.831 10 (7), p = 0.455 61/98 (62), p = 0.748 18 (14), p = 0.960 62 (48), p = 0.949 5 (4), p = 0.416 49 (44), p = 0.727 6 (4?), p = 0.780 4 (2?), p = 0.466 77 (57), p = 0.361 p = 0.002 89 (64) 38 (27) 5 (4) 7 (5)Missing data (out of n = 246) 0 0 5 16 11 12 93 14 16 22 49 10 11 9Blood pressure lowering medication*, n ( ) 141 (60) Dementia categories Alzheimer’s disease, n ( ) DLB/PDD, n ( ) Vascular dementia, n ( ) FTD/alcoholic dem., n ( )IQR = interquartile range; MMSE = Mini-Mental State Examination, normal range 24?0; AD = Alzheimer’s Disease; DLB = Dementia with Lewy Bodies; PDD = Parkinson’s Disease Dementia; VaD = vascular dementia; FTD = Frontotemporal Dementia; CIRS = Cumulative Illness Rating Scale, range 0 (no impairment)-52 (extremely severe impairment); APOE = Apolipoprotein E. *antianginals, antihypertensives, tricyclic antidepressants, paroxetine,MAO inhibitors, dopamine agonists, diazepam, dipyridamole, phenothiazines, clozapine, quetiapine, haloperidol. Significant results are shown in bold typeface. doi:10.1371/MK 8931 site journal.pone.0052196.twhereas in our study only a minority (17 ) had clinically significant depression (defined as a Montgomery Asberg De-pression Rating Scale [40] score of at least 15). In the other studies [15,17], a majority of the relevant subjects had DLB, known toTable 2. Demographic and clinical characteristics, lowest vs. highest WMH quartile.Volumetry group OH (fractions) Systolic BP drop (median)* Diastolic BP drop (median)* Standing 12926553 syst. BP#110 (fractions) Age (median)* Women (fractions) AD (fractions) Hypertension (fractions) Coronary heart disease (fractions) Diabetes mellitus (fractions) APOEe4 1 allele (fractions) Previous stroke.Artile were significantly older than those in the lowest quartile, and the proportion of patients with a previous stroke was significantly higher in the highest quartile. Otherwise, there wereDiscussionThe main finding of our study is that in this sample of older people with mild dementia, WMH were 1326631 not associated with OH or low standing systolic BP. Only APOEe4 status (volumetry) and age (volumetry and semi-quantitative analysis) were independently associated with WMH volumes. Thus, our hypothesis that WMH in mild dementia are associated with OH was not supported. This finding is in contrast to some previous studies. However, some of these studies were performed in older people with major depression [16,18,19],OH and WMH in Mild DementiaTable 1. Demographic and clinical characteristics.Total sample Volumetry group (n = 82), vs. rest Semi-quantitative group (n = 139), vs. n = 246 of sample rest of sample Age, median (IQR) Women, n ( ) MMSE, median (IQR) Coronary heart disease, n ( ) Hypertension (history of), n ( ) Diabetes mellitus, n ( ) APOEe4 1 allele, fractions ( ) Previous stroke, n ( ) Smoker (former/pres.), n ( ) Heart failure, n ( ) Orthostatic hypotension (present), n ( ) CIRS score, median (IQR) No. of drugs, median (IQR) 76.9 (71?1) 139 (57) 24 (22?6) 49 (21) 109 (46) 21 (9) 93/153 (61) 33 (14) 111 (48) 12 (5) 90 (46) 6 (4?) 4 (2?) 76.1 (70?1), p = 0.502 51 (62), p = 0.256 24 (22.5?6), p = 0.217 15 (19), p = 0.704 30 (38), p = 0.115 9 (11), p = 0.495 31/53 (59), p = 0.803 8 (10), p = 0.302 37 (47), p = 0.862 2 (3), p = 0.227 35 (47), p = 0.945 6 (4?), p = 0.402 4 (2?), p = 0.159 41 (53), p = 0.167 p = 0.000 138 (56) 89 (36) 11 (4) 8 (3) 60 (73) 16 (20) 2 (2) 4 (5) 76.5 (71?1), p = 0.562 84 (60), p = 0.198 23.3 (22?5), p = 0.377 27 (21), p = 0.949 63 (47), p = 0.831 10 (7), p = 0.455 61/98 (62), p = 0.748 18 (14), p = 0.960 62 (48), p = 0.949 5 (4), p = 0.416 49 (44), p = 0.727 6 (4?), p = 0.780 4 (2?), p = 0.466 77 (57), p = 0.361 p = 0.002 89 (64) 38 (27) 5 (4) 7 (5)Missing data (out of n = 246) 0 0 5 16 11 12 93 14 16 22 49 10 11 9Blood pressure lowering medication*, n ( ) 141 (60) Dementia categories Alzheimer’s disease, n ( ) DLB/PDD, n ( ) Vascular dementia, n ( ) FTD/alcoholic dem., n ( )IQR = interquartile range; MMSE = Mini-Mental State Examination, normal range 24?0; AD = Alzheimer’s Disease; DLB = Dementia with Lewy Bodies; PDD = Parkinson’s Disease Dementia; VaD = vascular dementia; FTD = Frontotemporal Dementia; CIRS = Cumulative Illness Rating Scale, range 0 (no impairment)-52 (extremely severe impairment); APOE = Apolipoprotein E. *antianginals, antihypertensives, tricyclic antidepressants, paroxetine,MAO inhibitors, dopamine agonists, diazepam, dipyridamole, phenothiazines, clozapine, quetiapine, haloperidol. Significant results are shown in bold typeface. doi:10.1371/journal.pone.0052196.twhereas in our study only a minority (17 ) had clinically significant depression (defined as a Montgomery Asberg De-pression Rating Scale [40] score of at least 15). In the other studies [15,17], a majority of the relevant subjects had DLB, known toTable 2. Demographic and clinical characteristics, lowest vs. highest WMH quartile.Volumetry group OH (fractions) Systolic BP drop (median)* Diastolic BP drop (median)* Standing 12926553 syst. BP#110 (fractions) Age (median)* Women (fractions) AD (fractions) Hypertension (fractions) Coronary heart disease (fractions) Diabetes mellitus (fractions) APOEe4 1 allele (fractions) Previous stroke.