On is that only a small subset of post-dilatations is done with semi-compliant balloons but the exact numbers are unknown and this must be taken into account when interpreting our results. When analyzing data from very large databases, like SCAAR, there is a risk of finding statistically significant differences which do not translate into biologically meaningful information. We have tried to avoid this by viewing the data in different ways both depicting cumulative incidences and risks at 1 year and performing separate analyses in patients stented for the first time and only receiving a single stent. In 15900046 our view the message lingering is that there could be MedChemExpress Chebulagic acid increased risks of restenosis and stent thrombosis at pressure extremes and adjunct post-dilatation could be associated with an increased risk of restenosis. It is important to consider that PCI operators decision of balloon inflation pressure and whether or not to use post-dilatation cannot be considered subjective choices but are largely driven by achieving the best possible angiographic results. This interplay between plaque composition and operator decision cannot be deducted from our data. However, all different lesion subsets were included and analysed in the adjusted analyses but our findings must be interpreted with a grain of salt because 
of known and unknown factors not adjusted for in our statistical model. Further studies are therefore needed to crack the possible biological and clinical impact.Post-dilatationStent balloons are usually semi-compliant but an optimal stent expansion as documented by intravascular ultrasound cannot be ensured by inflation to very high pressures. Typically, high inflation pressures of semi-compliant stent balloons result in earlier opening, larger diameter and thus increased wall stress in the extreme proximal and distal ends during stent expansion ?socalled “dogboning” [20]. Based on smaller studies but without offset in randomized trials post-dilatation with an NC balloon to ensure optimal stent expansion has been a standing recommendation within the PCI community. However, post-dilatation is not without risks. The procedure involves advancement of yet another catheter and accurate ML-281 biological activity placement of the NC balloon within the borders of the stent is not always achieved and this may result in edge dissection, geographic miss [21], or even coronary perforation [22]. These complications typically lead to additional stenting or target lesion revascularization at a later stage. Another possible complication with post-dilatation is longitudinal stent deformation ?a problem which seems more likely with conformable newer generation stents with thin struts [23]. Our findings of a higher restenosis risk following post-dilatation was remarkable and the gradual and continuing separation 
of the Kaplan-Meier curves (Figure 4B) points towards a biological explanation. One explanation could be that post-dilatation in itself is injurious. Another possible explanation could be that operators tend to use this adjunct in PCIs of lesions confined with a known increased risk of restenosis ?e.g. restenotic, long or calcific lesions, small vessels, bifurcations, chronic total occlusions or lesions inConclusions and clinical implicationsThis retrospective study of 93 697 stent implantations representing all eligible procedures in Sweden during more than 3.5 years identified a possible biological pattern – the risks of stent thrombosis and of restenosis appeared to be hi.On is that only a small subset of post-dilatations is done with semi-compliant balloons but the exact numbers are unknown and this must be taken into account when interpreting our results. When analyzing data from very large databases, like SCAAR, there is a risk of finding statistically significant differences which do not translate into biologically meaningful information. We have tried to avoid this by viewing the data in different ways both depicting cumulative incidences and risks at 1 year and performing separate analyses in patients stented for the first time and only receiving a single stent. In 15900046 our view the message lingering is that there could be increased risks of restenosis and stent thrombosis at pressure extremes and adjunct post-dilatation could be associated with an increased risk of restenosis. It is important to consider that PCI operators decision of balloon inflation pressure and whether or not to use post-dilatation cannot be considered subjective choices but are largely driven by achieving the best possible angiographic results. This interplay between plaque composition and operator decision cannot be deducted from our data. However, all different lesion subsets were included and analysed in the adjusted analyses but our findings must be interpreted with a grain of salt because of known and unknown factors not adjusted for in our statistical model. Further studies are therefore needed to crack the possible biological and clinical impact.Post-dilatationStent balloons are usually semi-compliant but an optimal stent expansion as documented by intravascular ultrasound cannot be ensured by inflation to very high pressures. Typically, high inflation pressures of semi-compliant stent balloons result in earlier opening, larger diameter and thus increased wall stress in the extreme proximal and distal ends during stent expansion ?socalled “dogboning” [20]. Based on smaller studies but without offset in randomized trials post-dilatation with an NC balloon to ensure optimal stent expansion has been a standing recommendation within the PCI community. However, post-dilatation is not without risks. The procedure involves advancement of yet another catheter and accurate placement of the NC balloon within the borders of the stent is not always achieved and this may result in edge dissection, geographic miss [21], or even coronary perforation [22]. These complications typically lead to additional stenting or target lesion revascularization at a later stage. Another possible complication with post-dilatation is longitudinal stent deformation ?a problem which seems more likely with conformable newer generation stents with thin struts [23]. Our findings of a higher restenosis risk following post-dilatation was remarkable and the gradual and continuing separation of the Kaplan-Meier curves (Figure 4B) points towards a biological explanation. One explanation could be that post-dilatation in itself is injurious. Another possible explanation could be that operators tend to use this adjunct in PCIs of lesions confined with a known increased risk of restenosis ?e.g. restenotic, long or calcific lesions, small vessels, bifurcations, chronic total occlusions or lesions inConclusions and clinical implicationsThis retrospective study of 93 697 stent implantations representing all eligible procedures in Sweden during more than 3.5 years identified a possible biological pattern – the risks of stent thrombosis and of restenosis appeared to be hi.